Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors

• Sedat Ünal,
• Gamze Varan,
• Juan M. Benito,
• Yeşim Aktaş and
• Erem Bilensoy

Beilstein J. Org. Chem. 2023, 19, 139–157, doi:10.3762/bjoc.19.14

Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

• Luke O. Jones,
• Leah Williams,
• Tasmin Boam,
• Martin Kalmet,
• Chidubem Oguike and
• Fiona L. Hatton

Beilstein J. Org. Chem. 2021, 17, 2553–2569, doi:10.3762/bjoc.17.171

• the hydrophobic state of the polymer network at physiological temperature and the method of drug immobilisation. Additionally, cryogels based on other polymers such as polyacrylamide (PAAm), PNIPAM and poly(2-hydroxyethyl methacrylate) (PHEMA), obtained via the same method reported by Kostava et al

An initiator- and catalyst-free hydrogel coating process for 3D printed medical-grade poly(ε-caprolactone)

• Jochen Löblein,
• Thomas Lorson,
• Miriam Komma,
• Tobias Kielholz,
• Maike Windbergs,
• Paul D. Dalton and
• Robert Luxenhofer

Beilstein J. Org. Chem. 2021, 17, 2095–2101, doi:10.3762/bjoc.17.136

• photopolymerization for the hydrophilic modification of microfiber scaffolds obtained from hydrophobic medical-grade poly(ε-caprolactone) via melt-electrowriting. Contact angle measurements and Raman spectroscopy confirms the formation of a more hydrophilic coating of poly(2-hydroxyethyl methacrylate). Apart from

• demonstrate this surface modification using a hydrogel, poly(2-hydroxyethyl methacrylate) (PHEMA) [19]. However, this approach should have broad utility for a spectrum of monomers and macromonomers susceptible to radical polymerization onto (almost) any surface featuring C–H bonds. This hydrogel coating is

Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier

• Yamei Zhao,
• Wei Tian,
• Guang Yang and
• Xiaodong Fan

Beilstein J. Org. Chem. 2014, 10, 2696–2703, doi:10.3762/bjoc.10.284

• (Scheme 1D) and simultaneously perform three functionalities including high loading, multiregion encapsulation, and controlled release (Scheme 1E). As prepared ABC, consisting of two hydrophobic poly[2-hydroxyethyl methacrylate] (PHEMA) blocks and one hydrophilic poly(N,N-dimethylaminoethyl methacrylate

Loose-fit polypseudorotaxanes constructed from γ-CDs and PHEMA-PPG-PEG-PPG-PHEMA

• Tao Kong,
• Lin Ye,
• Ai-ying Zhang and
• Zeng-guo Feng

Beilstein J. Org. Chem. 2014, 10, 2461–2469, doi:10.3762/bjoc.10.257

• knowledge, self-assembled PPRs from γ-CDs with the bulkier poly(2-hydroxyethyl methacrylate) (PHEMA)-flanked block copolymers have not yet been reported. Herein, a pentablock copolymer PHEMA-PPO-PEO-PPO-PHEMA is prepared via atom transfer radical polymerization (ATRP) in DMF, and allowed to self-assemble

• analyses indicated that γ-CDs can accommodate and slip over PHEMA blocks to randomly distribute along the entire pentablock copolymer chain. This results in unique, single-chain stranded PPRs showing no characteristic channel-type crystal structure. Keywords: block copolymer; γ-CD; loose-fit; poly(2

• -hydroxyethyl methacrylate); polypseudorotaxane; Introduction Cyclodextrins (CDs) are a family of cyclic oligosaccharides composed of 6, 7 or 8 glucose units linked via α-1,4-glycosidic bonds. Due to the presence of a hydrophobic inner cavity with different geometric dimensions, CDs can act as host molecules

Miniemulsion polymerization as a versatile tool for the synthesis of functionalized polymers

• Daniel Crespy and
• Katharina Landfester

Beilstein J. Org. Chem. 2010, 6, 1132–1148, doi:10.3762/bjoc.6.130

• polymethacrylic acid [17], polyacrylic acid, i.e., poly(acrylic acid) and poly(acrylic acid sodium salt) [18][19][20], and poly(2-hydroxyethyl methacrylate) [18][21] were synthesized in inverse w/o miniemulsions. The polymerization of 2-hydroxyethyl methacrylate could be performed in inverse miniemulsion with a

• diacrylate to yield, after the transfer to water, stable microgels. Monodisperse latexes could be obtained with the poly(2-hydroxyethyl methacrylate) when water, methanol, ethanol, ethylene glycol, or water/ethanol mixtures were used as the dispersed phase in the presence of cobalt tetrafluoroborate [21